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88 Bhat, M; Toledo-Velasquez, D; Wang, L Y; Malanga, C J; Ma, J K H; Rojanasakul, Y, Regulation of tight junction permeability by calcium mediators and cell cytoskeleton in rabbit tracheal epithelium, Pharm Res 10, 991 997 (1993) 89 Noach, A B J Enhancement of paracellular drug transport across epithelia in vitro and in vivo studies, Pharm World Sci 17, 58 60 (1995) 90 Lutz, K L; Jois, S D S; Siahaan, T J, Secondary structure of the HAV peptide which regulates cadherin-cadherin interaction, J Biomol Struct Dynam 13, 447 455 (1995) 91 Tanaka, Y; Taki, Y; Sakane, T; Nadai, T; Sezaki, H; Yamashita, S, Characterization of drug transport through tight-junctional pathway in Caco-2 monolayer: Comparison with isolated rat jejunum and colon, Pharm Res 12, 523 528 (1995) 92 Brayden, D J; Creed, E; Meehan, E; O Malley, K E, Passive transepithelial diltiazem absorption across intestinal tissue leading to tight junction openings, J Control Rel 38, 193 203 (1996) 93 Lutz, K L; Szabo, L A; Thompson, D L; Siahaan, T J, Antibody recognition of peptide sequence from the cell-cell adhesion proteins: N- and E-cadherins, Peptide Res 9, 233 239 (1996) 94 Borchard, G; Lue en, H L; de Boer, A G; Verhoef, J C; Lehr, C-M; Junginger, H E, The potential of mucoadhesive polymers in enhancing intestinal peptide drug absorption III: Effects of chitosan-glutamate and carbomer on epithelial tight junctions in vitro, J Control Rel 39, 131 138 (1996) 95 Lutz, K L; Siahaan, T J, Molecular structure of the apical junction complex and its contributions to the paracellular barrier, J Pharm Sci 86, 977 984 (1997) 96 Pal, D; Audus, K L; Siahaan, T J, Modulation of cellular adhesion in bovine brain microvessel endothelial cells by a decapeptide, Brain Res 747, 103 113 (1997) 97 Gan, L-S L; Yanni, S; Thakker, D R, Modulation of the tight junctions of the Caco-2 cell monolayers by H2-antagonists, Pharm Res 15, 53 57 (1998) 98 Hansch, C; Leo, A, Substituent Constants for Correlation Analysis in Chemistry and Biology, Wiley-Interscience, New York, 1979 99 Iwahashi, M; Hayashi, Y; Hachiya, N; Matsuzawa, H; Kobayashi, H, Self-association of octan-1-ol in the pure liquid state and in decane solutions as observed by viscosity, selfdiffusion, nuclear magnetic resonance and near-infrared spectroscopy measurements, J Chem Soc Faraday Trans 89, 707 712 (1993) 100 Franks, N P; Abraham, M H; Lieb, W R, Molecular organization of liquid n-octanol: An X-ray diffraction analysis, J Pharm Sci 82, 466 470 (1993) 101 Amidon, G L; Lennernas, H; Shah, V P; Crison, J R, A theoretical basis for a biopharmaceutic drug classi cation: the correlation of in vitro drug product dissolution and in vivo bioavailability, Pharm Res 12, 413 420 (1995) 102 Amidon, G L, The rationale for a biopharmaceutics drug classi cation, in Biopharmaceutics Drug Classi cation and International Drug Regulation, Capsugel Library, 1995, pp 179 194 103 Amidon, G L; Walgreen, C R, Rationale and implementation of a biopharmaceutics classi cation system (bcs) for new drug regulation, in Biopharmaceutics Drug Classi cation and International Drug Regulation, Capsugel Library, 1998, pp 13 27 104 Hussain, A S, Methods for permeability determination: A regulatory perspective AAPS Workshop on Permeability De nitions and Regulatory Standards for Bioequivalence, Arlington, VA, Aug 17 19, 1998.

The possibility of excessive concentration of the tracer compound in certain biological tissues and the degree of radiosensitivity of these tissues must also be carefully considered, especially when a- or b2-emitting tracers are used Fortunately, the excellent sensitivity of most radioactivity assay methods minimizes the need to employ tracer doses of such a magnitude that any detectable radiation damage occurs The possibilities of interference due to physiological response to radiation are further minimized because most studies are short term and thus completed before any latent radiation effects appear In physical tracer studies, the radiation damage produced by the decaying nuclei must not so destroy the crystal structure and similar features as to modify the experimental results In addition, one must remember that as the result of radioactive decay, the daughter atom is usually a different chemical element than the mother atom.

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One must be sure that the presence of these foreign species and any related equilibria does not affect the observations (For example, if both the mother and daughter atoms are b2 emitters, then one might see a increase in the count rate due to the inability to distinguish the b2 particles from the tracer and its daughter).

1 To create the list box, double-click the grid that contains the artwork for the audio player to make it the active container Then click the ListBox button in the Toolbox, and click and drag in the grid to create the list box there You can use the Layout palette to finetune the list box s size and location Then right-click on the list box and choose Add ListBoxItem Do this for as many files as you want in your audio player 2 To add the audio files into the project, choose Project Add Existing Item, navigate to your files, select them, and click Open The files appear in the Files palette of the Project panel 3 Double-click the audio player to make it active 4 Click the Create New Timeline button in the Objects and Timeline palette.

COACHING INTO GREATNESS I m not saying that benchmarks and measures are bad it s when they keep us from seeing possibilities and being open to change that they are no longer helpful We re so quick to quantify our lives that we ve forgotten what makes us alive Individually and as a society we must move from the external de nitions of who we are to remembering the internal de nitions of our greatness Then and only then will be we happy Just as I challenged you with a new way of looking at scarcity, we must do the same with abundance Abundance is not simply the opposite of scarcity Abundance is a state of mind in which individuals exercise the freedom to be who they are Abundance is waking up to the reality that you are already the person you yearn to become, and that you already have everything you need It is the denial, or more likely resistance of one s true nature that keeps you in scarcity Abundance is about falling in love with who and where you are It is focusing on all that you have, and not losing yourself in all that you don t have In the end, though, it is an abundance mentality that allows each of us to do what we can do in each moment, and that s exactly how we Live into our Greatness

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